Thursday, January 19, 2017

New solutions to treat dry eye disease are progressing successfully

Dry eye specialty optometrists may soon be able to add new tools to their treatment arsenal, as
international research progresses on new therapies.

Researchers at the University of Virginia hope that a natural protein found in tears may one day offer relief to dry eye patients.

University of Virginia cell biologist, Professor Gordon Laurie, was part of the team that discovered the protein – which was named lacritin – using biochemical screening. Later studies showed that its active form, which lubricates the cornea, is frequently missing in dry eye patients.

Professor Laurie and his fellow researchers have now created an eye drop called Lacripep that replaces lacritin in the eye.

Working as part of the new spin-out company TearSolutions, Professor Laurie told OT that he will launch a four-week, early stage clinical trial for 201 patients with Sjögren’s syndrome. Patients will receive a placebo or Lacripep, in either a low or a high dose.

“This is a small step in our mission to provide…dry eye sufferers with a truly effective treatment,” Professor Laurie highlighted.

Closer to market are Seciera eye drops, a new formation using the immunosuppressant cyclosporine A enclosed in spheres of molecules at the nanometre scale.

After the medication demonstrated quick and effective action on 455 patients over 12 weeks of treatment, its owner Sun Pharma is planning to launch the eye drop in Europe, the US and Japan.

Sun Pharma managing director, Dilip Shanghvi, emphasised that: “These results are highly encouraging for millions of dry eye patients across the globe that have yet to find relief for their condition.”

Image credit: Jesse Vislisel, Brice Critser

Tuesday, January 10, 2017

Retinal Migraine: Causes, Symptoms, and Treatment

A retinal migraine is one of many types of migraine. A retinal migraine is rare, and it is different from a migraine headache or a migraine with aura. Those conditions usually affect the vision in both eyes. A retinal migraine affects vision in one eye only.

Around 1 in every 200 people who get migraines will have a retinal migraine.

The condition is also sometimes called an ophthalmic migraine, visual migraine, or an ocular migraine, although symptoms for these are slightly different.

A retinal migraine can cause temporary blindness or visual problems in one eye. Retinal migraines usually last for up to 1 hour and are followed by the return of normal vision.

Causes of a retinal migraine

A retinal migraine is caused by a reduction in blood flow to the eye when blood vessels narrow suddenly. There are several reasons why this might happen.

Factors that might trigger blood vessel narrowing and retinal migraines include:
  • Bending over
  • Birth control pills
  • Dehydration
  • Excessive heat
  • Exercise
  • High altitude
  • High blood pressure
  • Low blood sugar
  • Stress
  • Smoking

As the blood vessels relax and blood flow returns to normal, the symptoms usually disappear and vision comes back.

Some people are more at risk of a retinal migraine than others. These people include:
  • People aged 40 years and under
  • Individuals with a family history of migraines
  • People with another condition, such as atherosclerosis, epilepsy, lupus, and sickle cell disease
It affects women more often than men.

Symptoms

Retinal migraines involve repeated attacks of certain visual disturbances. These usually happen before the headache phase of a migraine. The visual disturbances are often collectively referred to as "aura."

Symptoms occur in one eye. The characteristics of an aura may include:
  • Seeing flashing, sparkling, or twinkling lights
  • A blind spot or partial loss of vision
  • Temporary blindness
The aura may spread gradually over 5 minutes or more and last for 6-60 minutes. Within 60 minutes of visual symptoms, the headache phase of a retinal migraine may begin.

The headache phase of a retinal migraine has symptoms like a migraine without aura. These symptoms include a headache that lasts 4 to 72 hours on one side of the head.

The headache may be:
  • Pulsing or throbbing
  • Moderate to severe in pain intensity
  • Made worse by activities such as walking or climbing stairs
A migraine headache may also cause:
  • Nausea and vomiting
  • Increased sensitivity to light
  • Increased sensitivity to sound
A migraine with aura is a different condition to a retinal migraine, although some of the symptoms are similar.

Migraines with aura also cause visual disturbances such as flashes of light, blind spots, and other visual changes. However, a retinal migraine differs from a migraine with aura for two main reasons:
  • The visual symptoms only occur in one eye and not both
  • Complete but temporary blindness may occur in one eye only
Diagnosis

There are no diagnostic tests that detect a retinal migraine. A doctor may diagnose a retinal migraine by examining personal and family medical history, asking about symptoms, and conducting an examination.

Other possible causes for the symptoms will be ruled out before a retinal migraine is diagnosed. It is important to investigate and rule out other causes of temporary blindness.

A specialist doctor might need to ensure that the symptoms are not caused by a serious eye disease or stroke.

Some people that have visual disturbances in one eye might have hemianopia. Hemianopia is the loss of vision on the same side in both eyes. This condition often happens in stroke and traumatic brain injuries.

Treatments

The medication that a doctor prescribes to treat retinal migraines may change depending on a person's age and how frequently they have retinal migraine attacks.

Prescribed medication might include:
  • Non-steroidal anti-inflammatory drugs(NSAIDs), such as aspirin or ibuprofen, to relieve pain and inflammation
  • Antinausea medications to prevent nausea and vomiting
  • Ergotamines to narrow blood vessels in the brain to relieve a headache
  • Triptans to narrow blood vessels in the brain and reduce swelling
  • Beta-blockers to relax blood vessels in the brain
  • Calcium channel blockers to prevent blood vessels constricting
  • Antidepressants to help prevent a migraine
  • Anticonvulsants to help prevent a migraine
There is currently a lack of research into the best way to treat a retinal migraine. However, most treatments focus on pain relief for headaches and reducing exposure to potential retinal migraine triggers.

Outlook

Most people that have retinal migraines will usually experience an attack every few months. The visual disturbance phase tends to last no more than an hour, and the subsequent headache can last anywhere from a few hours to a few days.

A retinal migraine is difficult to diagnose. It is often misdiagnosed as another condition or as a common migraine. While there is no cure for the condition, it can be managed and prevented through medication and avoiding triggers.

Currently, retinal migraines are not fully understood, but research is ongoing. The investigation into migraine prevention is in progress, but, as yet, there is no proven cure.